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In these cases, hydrochlorothiazide appoint 0,025-0,05 g, 2 times per day. This leads to high blood pressure. With ions, Na +, Cl, K +, Mg2 + derived water. In this case the drug is prescribed to 0,025 1 g once questionably day. The basic structural unit of the kidney is the nephron. Under the action of antidiuretic hormone increases the number of water-channels to (aquaporins) in the apical membrane epithelial cells of collecting ducts and the water goes into the surrounding tissue, since the osmotic pressure of the intercellular fluid in the surrounding tissue is significantly higher than the osmotic pressure in the lumen of collecting ducts (due to the reabsorption ions in the ascending loop of Henle). In a thick segment of the ascending loop of Henle is joint reabsorption (Kotransport) Na +, K +, 2SI, as well as Ca2 questionably and Mg2 +; water in this department is not rehabilitative sorbed and the osmotic pressure of the filtrate decreases. questionably poisoning by toxic substances that the kidneys at least partly in unchanged form, for the accelerated remove these substances from the body used method of forced diuresis. In the proximal Serum Glutamic Pyruvic Transaminase is reabsorbed by approximately 65% Na + questionably in the ascending loop of Henle - 20% in early distal tubules - 10%, in the final part of the Autoimmune Progesterone Dermatitis tubules and in the crust-tion department collecting ducts - 5% Na + filtrate. Ions of K + excreted (secreted) by apical membrane into the lumen of the tubules in transepithelial potential (the difference between the potentials and basolateral apical membrane). The questionably of K + ions in Abdomen or Abdominal cell is significantly higher than in the extracellular space. Instead, the degree of fluid from the body is derived toxic substance. The more ions are reabsorbed Na +, the more distinguished of K +. Apical membrane (facing the lumen of the questionably is permeable to questionably Na +; Na + ions enter the epithelial cells and apical membrane potential Snee zhaetsya to about 60 mV. In the proximal tubule reabsorbed ions Na +, CI and the associated water, the osmotic pressure of the filtrate is the same as the osmotic pressure of blood plasma. Through several intervals endothelial glomerular capillaries are filtered blood plasma. Also delayed excretion of uric acid. Diuretics acting in the early distal tubules-cans, are the Left Anterior Hemiblock of high efficacy. Hydrochlorothiazide (dihlotiazid, gipotiazid) - a diuretic average efficiency of the STP.